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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HNF4A
All Species:
26.36
Human Site:
T166
Identified Species:
48.33
UniProt:
P41235
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41235
NP_849180.1
474
52785
T166
E
V
L
S
R
Q
I
T
S
P
V
S
G
I
N
Chimpanzee
Pan troglodytes
XP_514664
468
51900
T170
A
L
L
Q
A
E
I
T
S
P
V
S
G
I
N
Rhesus Macaque
Macaca mulatta
XP_001110097
452
49945
A166
G
I
N
G
D
I
R
A
K
K
I
A
S
I
A
Dog
Lupus familis
XP_852731
474
52640
T166
E
V
L
S
Q
Q
I
T
S
P
V
S
G
I
N
Cat
Felis silvestris
Mouse
Mus musculus
P49698
474
52665
T166
E
V
L
S
Q
Q
I
T
S
P
I
S
G
I
N
Rat
Rattus norvegicus
P22449
474
52693
T166
E
V
L
S
Q
Q
I
T
S
P
I
S
G
I
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507309
419
46844
T153
D
S
S
L
P
S
I
T
A
L
L
Q
A
E
A
Chicken
Gallus gallus
NP_001026026
454
50607
S157
E
V
L
A
Q
Q
I
S
S
P
V
L
V
M
N
Frog
Xenopus laevis
Q91766
464
51948
T166
E
V
L
S
Q
Q
I
T
S
S
V
G
V
L
N
Zebra Danio
Brachydanio rerio
A2T929
430
47452
C158
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49866
666
71882
A216
S
R
Q
S
K
A
G
A
A
M
E
P
N
I
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O44960
369
41820
D102
D
A
V
Q
T
E
R
D
R
I
R
P
A
N
P
Sea Urchin
Strong. purpuratus
XP_780389
468
51669
D157
K
K
I
A
T
M
N
D
V
C
E
S
M
K
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.6
90.9
98.3
N.A.
95.7
96.1
N.A.
79.5
84.1
80.8
33.7
N.A.
42.4
N.A.
33.9
57.1
Protein Similarity:
100
82.9
91.9
99.1
N.A.
97
97.4
N.A.
84.8
89.8
89.6
51.4
N.A.
54.5
N.A.
49.5
72.3
P-Site Identity:
100
66.6
6.6
93.3
N.A.
86.6
86.6
N.A.
13.3
60
66.6
6.6
N.A.
20
N.A.
0
6.6
P-Site Similarity:
100
80
26.6
100
N.A.
100
100
N.A.
33.3
86.6
80
20
N.A.
33.3
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
16
8
8
0
16
16
0
0
8
16
0
24
% A
% Cys:
0
0
0
0
8
0
0
8
0
8
0
0
8
0
0
% C
% Asp:
16
0
0
0
8
0
0
16
0
0
0
0
0
0
0
% D
% Glu:
47
0
0
0
0
16
0
0
0
0
16
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
8
0
0
8
0
0
0
0
8
39
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
8
62
0
0
8
24
0
0
54
0
% I
% Lys:
8
8
0
0
8
0
0
0
8
8
0
8
0
8
0
% K
% Leu:
0
8
54
8
0
0
0
0
0
8
8
8
0
16
0
% L
% Met:
0
0
0
0
0
8
0
0
0
8
0
0
8
8
0
% M
% Asn:
0
0
16
0
0
0
8
0
0
0
0
0
8
8
62
% N
% Pro:
0
0
0
0
8
0
0
0
0
47
0
16
0
0
8
% P
% Gln:
8
0
8
16
39
54
0
0
0
0
8
8
0
0
8
% Q
% Arg:
0
16
0
8
8
0
16
0
16
0
8
0
0
0
0
% R
% Ser:
8
8
8
47
0
8
0
8
54
8
0
47
8
0
0
% S
% Thr:
0
0
0
0
16
0
0
54
0
0
0
0
0
0
0
% T
% Val:
0
47
8
0
0
0
0
0
8
0
39
0
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _